| dc.description.abstract | Introduction: Diabetic nephropathy is the most common cause of kidney
disease in diabetics. However, in some cases the clinical symptoms is not typ-
ical and nephropathy may be different from diabetic and require the use of
renal biopsy (RB) which is not usually indicated unless non-diabetic nephro-
pathy (NND) is suspected. The objective of this study was to evaluate the
prevalence of non-diabetic nephropathy (NDN) among the diabetic patients
and to analyse the different predictive factors of its occurrence. Patients and
methods: It was a retrospective, descriptive and analytical study which is car-
ried out at the nephrology department of Aristide Le DANTEC hospital of
Dakar over a period of 60 months. Diabetics with suspected NDN diagnosis
based on renal anomalie that is associated with a recent diabetes, Acute renal
failure with rapid progress, Diabetic retinopathy’s absence, and Extrarenal
signs (cutaneous, digestive and articular) associated with an acute renal fail-
ure. Microscopic haematuria was included. The epidemiological, clinical,
biological and histological parameters were collected and analysed using the
SPSS, 3.5 version software. Results: Out of 34 biopsied diabetic patients, 12
had NDN that is a prevalence of 35, 3%. The average age was 49.88 ± 4.15
years, 0.78 for the sex-ratio and the mean duration of diabetes is 12.53 ± 4.7
years. Glomerular syndrome was found in 30 patients (88.23%), vascular
nephropathy syndrome in 3 patients (8.82%) and tubule-interstitial neph-
ropathy syndrome in only one patient (2.94%). Diabetic retinopathy (DR)
and microscopic haematuria (HU) respectively existed in 10 patients (34%)
and 15 patients (44. 12%). The Kidney biopsy (KB) indications were renal
abnormalities associated with recent diabetes, acute renal failure with rapid progress, absence of DR, extrarenal signs associated with acute renal failure
and microscopic haematuria. Twenty-two patients (64.7%) had diabetic
nephropathy (DN) and 12 patients (38.2%) presented a NDN. Predictive fac-
tors of NDN diagnosis were a shorter diabetes duration (P = 0.0008), high
blood pressure (P = 0.0015) and absence of DR (P = 0.005). Conclusion: Our
data show that kidney injury in a diabetic is not always diabetic nephropathy.
The Kidney biopsy (KB) is often needed in order to adopt an effective man-
agement. | en_US |
