Browsing by Author "Cojean, Sandrine"
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Antiplasmodial activity of the ethanolic extract of icacina oliviformis (STEMS), spondias purpurea L.(leaves, barks and roots) and cocos nucifera L. (coconut shell fibers) from Ziguinchor, Senegal
Diatta, Armel; Sambou, Oumar; Gassama, Abdoulaye; Cojean, Sandrine; Cavé, Christian (2018)Icacina oliviformis (poiret) Raynal (Icacinaceae), Spondias purpurea L. (Anacardiaceae) and Cocos nucifera L. (Arecaceae) are Senegalese traditional pharmacopoeia plants used in the treatment of various diseases. These plants ... -
Evaluation of In Vitro Antiplasmodial Activity of Icacina oliviformis’s (Stems and Roots) and Spondias Purpurea’s (Leaves, Barks And Roots) Extracts from Ziguinchor, Senegal
Gassama, Abdoulaye; Diatta, Armel; Sambou, Oumar; Manga, Anastasie; Cojean, Sandrine; Cavé, Christian (2019)This study was designed to assess phytochemical and antiplasmodial activities of Icacina oliviformis’s and Spondias purpurea’s extracts. Icacina oliviformis (poiret) Raynal (Icacinaceae) and Spondias purpurea L. (Anacardiaceae) ... -
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
Seck, Rokhyatou; Gassama, Abdoulaye; Cojean, Sandrine; Cavé, Christian (2020)In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine ... -
Synthesis and antimalarial activity of cinnamic acid derivatives
Seck, Rokhyatou; Mansaly, Malamine; Gassama, Abdoulaye; Cavé, Christian; Cojean, Sandrine (2019)A peptide coupling reaction between 1-(R)-phenylethylalanine and cinnamic acid derivatives has been successfully employed for the synthesis of a set of small molecules. The antimalarial activity of these derivative molecules ... -
Synthesis and evaluation of the antimalarial activity of cinnamic acids derived from piperidine
Seck, Rokhyatou; Mansaly, Malamine; Gassama, Abdoulaye; Cavé, Christian; Cojean, Sandrine (2019)The synthesis and antimalarial activity of 1, 4-aminopiperidine derived cinnamic acids are described. Different analogs are prepared from reductive amination reactions and SN1 substitutions. These analogs are tested ...