Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl N-tert-Butanesulfinyl Hemiaminals
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Date
2013Author
Grellepois, Fabienne
Ben Jamaa, Abdelkhalek
Gassama, Abdoulaye
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The asymmetric synthesis of trifluoromethylated tertiary and
secondary carbinamines (α,α-dibranched and α-branched
amines) was achieved by reaction of alkyl, aryl and allyl organomagnesium or organolithium reagents to trifluoromethyl
N-tert-butanesulfinyl hemiaminals, bench-stable analogs of
the corresponding ketoimines.