Browsing by Author "Cavé, Christian"
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Antiplasmodial activity of extracts of Khaya senegalensis (Ders.) A. Jus (Meliaceae) and Melia azedarach L., plants of senegalese traditional medecine
Manga, Anastasie; Gassama, Abdoulaye; Diatta, K.; Bassène, Emmanuel; Cojean, Serge; Cavé, Christian (2018)Two medicinal plants (Khaya senegalensis and Melia azedarach), frequently used by a large part of the Senegalese population and in particular that of the natural region of Casamance in the traditional treatment of ... -
Antiplasmodial activity of the ethanolic extract of icacina oliviformis (STEMS), spondias purpurea L.(leaves, barks and roots) and cocos nucifera L. (coconut shell fibers) from Ziguinchor, Senegal
Diatta, Armel; Sambou, Oumar; Gassama, Abdoulaye; Cojean, Sandrine; Cavé, Christian (2018)Icacina oliviformis (poiret) Raynal (Icacinaceae), Spondias purpurea L. (Anacardiaceae) and Cocos nucifera L. (Arecaceae) are Senegalese traditional pharmacopoeia plants used in the treatment of various diseases. These plants ... -
Asymmetric synthesis of glutamate derivatives
Seck, Rokhyatou; Gassama, Abdoulaye; Nour, Mohammed; Demange, Luc; Cavé, Christian (2017)Analogs of glutamic acid were synthesized through the asymmetric Michael reaction using chiral acyclic E-enaminoesters and various Michael acceptors. The influence of the alkoxy group of the enaminoesters and also the ... -
Condensation of Chiral lmines and Chiral ]]-Enaminoesters with Maleic and Citraconic Anhydrides
Gassama, Abdoulaye; Cavé, Christian; Mahuteau, Jacqueline; Angelo, Jean d'; Riche, Claude (1997)Condenmlions of chiral imines I and 4, and chiral ennminoesters 10 and 13. ~ ma/e~ and citracoaic anhydrides were reported. These experimen:al om~com~ can be ratio _l~__~ed by invaking the compact, eado-aplaroaches of ... -
Enantioselective acces to five- and six- membered nitogen - containing heterocycles, based on the asymetric Michael addition of chiral imines and chiral enamino esters.
Angelo, Jean d'; Cavé, Christian; Gassama, Abdoulaye; Desmaële, Didier; Thominiaux, Cyrille; Riche, Claude (1998)The addition reaction of chiral imines, (ent-10, 48, 70) and chiral enamino esters (52, 55, 73) with maleic anhydride (32), citraconic anhydride (57), a-chloroacrylonitrile (29), and nitroethylene (74), has been investigated. ... -
Evaluation of In Vitro Antiplasmodial Activity of Icacina oliviformis’s (Stems and Roots) and Spondias Purpurea’s (Leaves, Barks And Roots) Extracts from Ziguinchor, Senegal
Gassama, Abdoulaye; Diatta, Armel; Sambou, Oumar; Manga, Anastasie; Cojean, Sandrine; Cavé, Christian (2019)This study was designed to assess phytochemical and antiplasmodial activities of Icacina oliviformis’s and Spondias purpurea’s extracts. Icacina oliviformis (poiret) Raynal (Icacinaceae) and Spondias purpurea L. (Anacardiaceae) ... -
Regioselective Annulation of 1,5-Diketones: Access to Functionalized Hagemann’s Esters
Gassama, Abdoulaye; Angelo, Jean d'; Cavé, Christian; Mahuteau, Jacqueline; Riche, Claude; (European Journal of Organic Chemistry, 2000)The synthesis of the ‘‘functionalized’’ Hagemann’s ester (S)- 18 was investigated. The common starting material in these approaches was enamino ester (S,Z)-5, which was prepared through the condensation of keto diester ... -
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
Seck, Rokhyatou; Gassama, Abdoulaye; Cojean, Sandrine; Cavé, Christian (2020)In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine ... -
Synthesis and antimalarial activity of cinnamic acid derivatives
Seck, Rokhyatou; Mansaly, Malamine; Gassama, Abdoulaye; Cavé, Christian; Cojean, Sandrine (2019)A peptide coupling reaction between 1-(R)-phenylethylalanine and cinnamic acid derivatives has been successfully employed for the synthesis of a set of small molecules. The antimalarial activity of these derivative molecules ... -
Synthesis and evaluation of the antimalarial activity of cinnamic acids derived from piperidine
Seck, Rokhyatou; Mansaly, Malamine; Gassama, Abdoulaye; Cavé, Christian; Cojean, Sandrine (2019)The synthesis and antimalarial activity of 1, 4-aminopiperidine derived cinnamic acids are described. Different analogs are prepared from reductive amination reactions and SN1 substitutions. These analogs are tested ...